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Amniotic membrane transplantation in acute severe ocular chemical injury: A randomized clinical trial

American Journal of Ophthalmology Feb 23, 2019

Eslani M, et al. - In this randomized, parallel-controlled clinical trial, researchers compared the consequences of conventional medical treatment and combined medical treatment plus amniotic membrane transplantation (AMT) in the management of Roper-Hall grade IV ocular chemical injury cases. They categorized the candidates: Group 1, cases who received topical preservative-free lubricating gel and drops, chloramphenicol, betamethasone, homatropine, oral vitamin C, and doxycycline, and Group 2 who received amniotic membrane transplant (AMT) on the intact ocular surface additionally to the medical treatment given in Group 1. They observed the healing of corneal epithelial defects within 72.6 ± 30.4 (21-180) days in Group 1 vs 75.8 ± 29.8 (46-170) days in Group 2. They recorded more central corneal neovascularization in Group 1 (73.3%) vs Group 2 (53.3%). Overall, they did not observe significant differences between the 2 therapies.
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