Meng L, Wang Z, Reilly M, et al. - Researchers sought to determine risk factors that can aid in recognision of the possibility of pregnancy loss in threatened late miscarriage (TLM) cases with and without spontaneous uterine contractions. They assayed amniotic immune biomarkers (IL2β receptor, IL6, IL8, IL10, IL1β, and TNFα), and assessed “sludge”. Treatment and follow up was performed of patients without intrauterine infections until delivery, and record of pregnancy outcomes was made. Per outcomes, TLM patients with and without contractions differed not only in terms of their amniotic immune biomarker levels and “sludge,” but also regarding the impact of these biomarkers on the pregnancy outcomes. They observed more late miscarriages and premature preterm rupture of membranes, and higher levels of amniotic IL2βR, IL8, and TNFα in the contractions group vs the no‐contractions group. In addition, only patients with and without “sludge” differed in amniotic immune biomarker levels in the contractions group. When considered individually, there was association of all six amniotic immune biomarkers with late miscarriage in the no‐contractions group but there was association of only IL10, IL8, IL1β, and TNFα in the contractions group. In the patients without contractions, only IL8 had an independent association and in patients with contractions, only TNFα had an independent association.