Weiner E, et al. - In this retrospective study, researchers assessed the correlation between amniotic fluid volume (AFV), plays an important role in early fetal lung development, at the time of presentation with early preterm premature rupture of membranes (PPROM) and severe neonatal respiratory morbidity and other adverse pregnancy outcomes. The study participants were all women with a singleton pregnancy admitted to a single tertiary referral center between 2004-2014 for expectant management of PPROM at 200/7-286/7 weeks’ gestation. Findings revealed that oligohydramnios and severe oligohydramnios at presentation were independently linked to severe respiratory morbidity vs normal AFV at presentation. Gestational age at PPROM, latency and cesarean delivery were other variables that were independently related to the primary outcome. In women with early PPROM, AFV at presentation has an independent association with severe neonatal respiratory morbidity, as assessed by the maximum vertical pocket on ultrasound examination. When advising women with early PPROM on neonatal outcomes and management options, this information may be taken into account.