Scofield RH, et al. - Ethnic groups of the United States were examined for the clinical and serological manifestations of Sjögren's syndrome (SS). In this cross-sectional study, researchers studied 648 patients with primary SS comprising 20 African-American (AA), 164 American Indian, 426 European-American and 38 of other races. SS was noted to affect American Indians at high rates but with few classical features that potentially prevents timely diagnosis in these cases. AA experience SS relatively infrequently and not with higher severity when compared to SLE, but extra vigilance for lymphomagenesis is recommended in relation to the triad of hypergammaglobulinemia, increased ESR and parotid enlargement.