Martins LB, de Miranda AS, dos Santos Rodrigues AM, et al. - In this cross‐sectional study, researchers compared the serum levels of the renin‐angiotensin system (RAS) components between patients with migraine (n = 30) and healthy controls (n = 20) and ascertained if these levels are correlated with migraine severity. They assumed that migraine will be correlated with the activation of the inflammatory arm of the RAS, likely resulting in increased levels of angiotensin (Ang) II. This investigation was carried out at Hospital das Clínicas (Universidade Federal de Minas Gerais, Belo Horizonte, Brazil) outpatient clinic. Using the Headache Impact Test, version 6 (HIT‐6) and the Migraine Disability Test (MIDAS) questionnaires, headache severity was evaluated.  Serum levels of angiotensin‐converting enzyme (ACE), ACE2, Ang II, and Ang (1‐7) have been measured by enzyme‐linked immunosorbent assay. The age, BMI, blood pressure, and depressive and anxious symptoms were comparable in patients with migraine and controls. Patients with migraine displayed lower levels of ACE and lower ACE/ACE2 ratio than controls. No associations were found between RAS serum markers and migraine severity scores (HIT and MIDAS) or depressive and anxious symptoms (BDI and BAI). Overall, the findings indicate that RAS is involved in migraine pathophysiology, but not in its severity.