Karska‐Basta I, Pociej‐Marciak W, Chrząszcz M, et al. - In the present study, the researchers sought to assess plasma levels of selected cytokines and examine their association with the choroidal thickness (CT) in patients with acute and chronic central serous chorioretinopathy (CSC). Thirty patients with acute CSC, 30 patients with chronic CSC, and 20 controls were enrolled. Using multiplex immunoassays, plasma concentrations of 12 cytokines, interleukins IL‐8, IL‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐10 and IL‐12 p70, granulocyte‐macrophage colony‐stimulating factor, interferon‐γ, tumour necrosis factor‐α (TNF‐α) and vascular endothelial growth factor (VEGF), were measured. Differences were noted in IL‐6, IL‐10, IL‐12 p70 and VEGF levels between groups. New evidence for the possible role of plasma cytokines in the pathogenesis of CSC was provided in this analysis. The findings indicate IL‐6 may be significant in acute and chronic CSC pathophysiology. The correlation between inflammatory response and hypertension was also reported in patients with CSC.