Guo X, Duan X, Chen H, et al. - Resting-state functional MRI data were investigated for 105 autism spectrum disorder (ASD) and 102 demographically matched typically developing control (TC) children accessible from the Autism Brain Imaging Data Exchange database in order to ascertain the temporal dynamics of intra- and interhemispheric functional connectivity patterns in ASD. In autistic children vs TC children, in the anterior cingulate cortex/medial prefrontal cortex, both intra- and interhemispheric comparisons exhibited raised dynamic functional connectivity density (dFCD) variability and reduced variability in the fusiform gyrus/inferior temporal gyrus. In sensorimotor regions involving the precentral/postcentral gyrus, autistic children additionally exhibited lower intrahemispheric dFCD variability. Furthermore, in autistic children, the severeness of social communication impairments was prognosticated by aberrant temporal variability of the contralateral dFCD. Thus, in brain regions involving social brain network of ASD, these outcomes exhibit modified temporal dynamics of the intra- and interhemispheric functional connectivity, and in neural substrates underlying impaired social processing in ASD, it reflects the possible role of abnormal interhemispheric communication dynamics.