Chong CD, et al. - Given a key role of the hypothalamus in both migraine and cluster headache (CH) and that structural and functional brain connectivity patterns are reflected in brain region-to-region structural correlations, researchers examined the structural covariance patterns between the volume of the hypothalamic region and vertex-by-vertex measurements of cortical thickness in patients with migraine and in those with CH relative to healthy controls (HC). Each group exhibited significant positive relationships between right and left hypothalamic region volumes with cortical thickness measurements. As per post-hoc analysis, there were significant disparities in covariance patterns in those with migraine and CH relative to HC; both migraine patients and CH exhibited weaker structural covariance of hypothalamic region volume with frontal and temporal cortical thickness. Findings suggest the importance of hypothalamic region connectivity to frontal and temporal areas for regulating pain perception. Hence, abnormal functioning of the pain control circuitry may be suggested by the diminished structural covariance in migraineurs and CH; this diminished structural covariance may contribute to mechanisms underlying central sensitization and chronification of pain.