Cho YN, Jeong HS, Park KJ, et al. - In order to find out the role of mucosal-associated invariant T (MAIT) cells in gouty arthritis (GA) and their effects on osteoclastogenesis, researchers recruited a total of 61 individuals with GA, 11 individuals with hyperuricaemia and 30 healthy controls. This study assessed MAIT cells, cytokines, CD69, programmed death-1 (PD-1) and lymphocyte-activation gene 3 (LAG-3) levels by flow cytometry. Using peripheral blood mononuclear cells, in vitro osteoclastogenesis experiments were conducted in the presence of M-CSF and RANK ligand. In GA individuals, circulating MAIT cells are activated and numerically deficient. The evidence showed that MAIT cells have the potential to migrate to inflamed tissues and induce osteoclastogenesis. The outcomes of this study, in GA individuals, provide an important role of MAIT cells in the pathogenesis of inflammation and bone destruction.