Hall JM, et al. - The structural organisation of the white matter connectome was examined by the authors in Parkinson’s disease (PD) freezers and PD non-freezers in order to comprehend the neural mechanisms of freezing of gait (FOG), a common symptom in advanced PD. Lower participation coefficients were illustrated in the right caudate, thalamus, and hippocampus, as well as within superior frontal and parietal cortical regions by freezers compared to non-freezers. Obtained data disclosed that changes in the structural network topology contributed to the manifestation of FOG in PD, specifically owing to the paucity of structural integration between key information processing hubs of the brain.