Blindbæk SL, et al. - In this 12-month prospective clinical trial, researchers analyzed changes in retinal microvascular structure in eyes treated with intravitreal aflibercept in combination with focal/grid laser photocoagulation for diabetic macular oedema (DME). The sample consisted of 32 treatment naïve eyes of 22 patients with centre involving DME. The treatment protocol consisted of a loading phase of three monthly aflibercept injections and focal/grid laser photocoagulation [baseline-month 3 (M3)] followed by a pro re nata (PRN) aflibercept phase until month 12 (M12). During the first year of DME treatment, early changes in retinal arteriolar calibre were linked to an increased treatment burden. Vessel calibre reduced both in eyes with and without need for PRN therapy at M3 as well as at M12 for retinal venules.