Haire G, Egan K, Parmar K, et al. - Researchers analyzed individuals with early-onset preeclampsia (N = 20) vs pregnant (N = 16) and non-pregnant controls (N = 16) for parameters of fibrin formation and fibrinolysis. Moreover, they correlated such parameters with markers of disease severity in this patient cohort, including the presence of multiorgan involvement, the rate of disease progression and the extent of the anti-angiogenic state in this condition. Women with early-onset preeclampsia and pregnant controls displayed significantly increased maximum rate of fibrin formation as well as PAI-1 (Plasminogen activator inhibitor 1), PAI-2 and D-dimer levels when compared with non-pregnant controls, without significant differences between the 2 former groups. In a similar manner, a significant reduction in plasmin-antiplasmin levels was noted. Early Onset Preeclampsia (EOP) vs pregnant and non-pregnant controls had significantly elevated tissue plasminogen activator levels. Significantly increased anti-angiogenic factors (soluble fm-like tyrsosine kinase 1; Endoglin) were noted in correlation with EOP vs both pregnant and non-pregnant controls.