Herzog K, Andersson T, Grill V, et al. - Findings revealed that changes in biomarker levels related to glycemia, lipid metabolism, and inflammation were linked with clinically diagnosed type 1 diabetes risk, and these could be increased many years preceding diagnosis.

• A total of 591,239 individuals from the Swedish AMORIS cohort followed from 1985–1996 to 2012 were analyzed to determine if increases in glycemic, lipid, and other metabolic biomarkers were related to future type 1 diabetes risk in adults.

• During follow-up (average age of patient at diagnosis: 53.3 years), a total of 1,122 type 1 diabetes cases were documented.

• The following were found to be positively linked with type 1 diabetes risk: biomarkers glucose, fructosamine, triglycerides, the ratio of apolipoprotein (apo)B to apoA-I, uric acid, alkaline phosphatase, and BMI.

• Higher apoA-I was identified to be related to lower type 1 diabetes incidence.

• Already 15 years prior to the diagnosis, patients with type 1 diabetes exhibited higher mean glucose, fructosamine, triglycerides, and uric acid levels than controls.