Johnson EF, et al. - Authors assessed the clinicopathologic and laboratory findings of alpha-1 antitrypsin deficiency (AATD) panniculitis in 10 patients. For a painful, ulcerative panniculitis with a predominantly neutrophilic histopathologic infiltrate, AATD panniculitis ought to be considered in the differential. With clinicopathologic correlation and genetic and laboratory evaluations, a diagnosis could be made. An assistance of serum AAT level and phenotype in diagnosing patients with suspected AATD panniculitis was noted. Most commonly nodular (100%), erythematous (90%), ulcerated (90%), and painful (90%) subcutaneous nodules and plaques clinical lesions were noted.