Amirdelfan K, Bae H, McJunkin T, et al. - This study was conducted to assess the safety and efficacy of a single intradiscal injection of STRO-3+ adult allogeneic mesenchymal precursor cells (MPCs) combined with hyaluronic acid (HA) in individuals with chronic low back pain (CLBP) correlated with degenerative disc disease (DDD) through 36-month follow-up. Researchers performed a multicenter, randomized, controlled study at 13 clinical sites (12 in the United States and 1 in Australia). The analysis included a total of 100 individuals with chronic low back pain associated with moderate DDD (modified Pfirrmann score of 3–6) at one level from L1 to S1 for at least 6 months and failing 3 months of conservative treatment, including physical therapy were assigned randomly in a 3:3:2:2 ratio to receive 6 million MPCs with HA, 18 million MPCs with HA, HA vehicle control, or saline control (placebo) treatment. The outcomes of this research demonstrate that intradiscal injection of MPCs could be a safe, effective, durable, and minimally invasive therapy for subjects who have CLBP associated with moderate DDD.