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Allergies and the subsequent risk of cancer among elderly adults in the United States

Cancer Epidemiology, Biomarkers & Prevention Mar 31, 2019

D'Arcy M, et al. - In a case–control study, researchers used Surveillance Epidemiology and End Results (SEER)-Medicare linked data to assess cancer risk among elderly Americans in relation to allergic rhinitis, asthma, and eczema. From SEER registries, individuals with a first cancer diagnosis were identified (1992–2013; aged 66–99 years; N=1,744,575). From Medicare, 100,000 cancer-free controls were randomly chosen and matched based on sex, age, and selection year. Inverse links with allergic rhinitis were found for multiple cancer types, including the hypopharynx, esophagus (squamous cell), cervix, tonsil/oropharynx, and vagina/vulva. They found more modest but significant inverse links for cancers of the esophagus (adenocarcinoma), stomach, colon, rectosigmoid/rectum, liver, gallbladder, lung, uterus, bladder, and miscellaneous sites. Attenuated risk of liver cancer was reported in relation to asthma whereas elevated risk of T-cell lymphoma was observed in relation to eczema.

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