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Aldosterone, salt, and potassium intakes as predictors of pregnancy outcome, including preeclampsia

Hypertension Jun 16, 2019

Birukov A, et al. - From the Odense Child Cohort—a Danish population-based longitudinal cohort study, researchers examined a subsample of 569 pregnant women to investigate whether aldosterone independently contributes to placental and birth weight in humans, and whether this link is adversely influenced by high dietary sodium and low potassium intakes. Using multiple and Cox regression analyses, they evaluated predictive values of aldosterone levels and sodium and potassium intakes. No link was found between aldosterone levels and preeclampsia incidence. Findings revealed an association of salt intake >6 g/d with preeclampsia development. At gestational week 29, urinary aldosterone excretion was identified as an independent predictor of placental and birth weights. In perspective, there exist adverse trophic impacts of suppression of aldosterone in pregnancy.
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