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Alcoholic and non-alcoholic fatty liver disease and associations with coronary artery calcification: Evidence from the Kangbuk Samsung Health Study

Gut Aug 14, 2019

Chang Y, Ryu S, Sung KC, et al. - In this cross-sectional study involving 105,328 Korean adults, researchers explored the connections between alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD) and coronary artery calcium (CAC) to examine if early liver disease due to AFLD or NAFLD have similar or dissimilar impacts on risk of early coronary artery atherosclerosis. Participants in the study were adults who attended a health check-up program. CAC score was positively related to both NAFLD and AFLD. In both non-obese and obese individuals associations of NAFLD and AFLD with CAC scores were similar without significant interaction by obesity. According to findings, the connections between fatty liver disease and CAC scores remained statistically significant after adjusting for homeostasis model assessment of insulin resistance and high-sensitivity C reactive protein. Early liver disease due to NAFLD and AFLD were both significantly linked to the presence of coronary artery calcification in this large sample of young and middle-aged people.

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