Akano EO, et al. - Using the National Inpatient Sample, researchers examined the link between alcohol abuse (AA) and alcohol withdrawal (AW) with acute ischemic stroke (AIS) outcomes (in-hospital medical complications, mortality, cost, and length of stay). They selected all adult AIS admissions in the US from 2004 to 2014 (weighted n = 4,438,968). The development of AW was noted in 10.6% of patients, signifying 0.4% of all AIS, out of the AA admissions. In AIS, a rise in the prevalence of AA and AW by 45.2% and 40.0%, respectively, was noted over time. Mainly men (80.2%) and whites (65.9%) and those in the 40- to 59-year (44.6%) and 60- to 79-year (45.6%) age groups constituted the group of patients with AA. Findings revealed that increased cost, longer hospitalizations, and higher odds of medical complications and in-hospital death following AIS were observed in correlation with AW. In order to better outcomes in these patients, proactive surveillance and management of AW may be necessary.