Evans-Polce RJ, Kcomt L, Veliz PT, et al. - Psychiatric comorbidities linked with alcohol use disorders and tobacco use disorders were examined among heterosexual, bisexual, and gay and lesbian men and women in the United States. Whether stress-related factors were predictive of comorbidities, was determined. They assessed data obtained from the National Epidemiologic Survey on Alcohol and Related Conditions–III (2012–2013, N = 36,309) and identified higher prevalence of comorbidities among women and sexual minorities, particularly bisexual women. Among sexual minorities, greater odds of comorbidities were found to be significantly correlated with the frequency of sexual orientation discrimination, number of stressful life events, and number of adverse childhood experiences. Significant inverse association of greater social support with tobacco use disorder comorbidities was observed. Findings thereby suggest the necessity for integrated substance use and mental health prevention and treatment programs, particularly for individuals who identify as sexual minorities.