Zeinomar N, Knight JA, Genkinger JM, et al. - In order to clarify if the reported links of alcohol intake and cigarette smoking with an increased risk of breast cancer (BC) differ by a woman’s familial BC risk, researchers performed this study using the Prospective Family Study Cohort. They not only examined the links between alcohol intake, cigarette smoking, and BC risk but also assessed if links were changed by familial risk profile (FRP), defined as the 1-year incidence of BC foretold by Breast Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), a pedigree-based algorithm. They performed a median follow-up of 10.4 years, analyzing 1,009 incident BC cases in 17,435 women. Findings revealed an increased BC risk in relation to moderate alcohol consumption, this was especially found for women with estrogen receptor-positive BC, but only for those at lower predicted familial BC risk (5-year BOADICEA < 1.25). A link between being a current smoker and an increased BC risk was revealed for women with a high FRP (5-year BOADICEA ≥ 6.5%) who also consumed alcohol.