Masaoka H et al. -The findings of the current study lend support to the notion that acetaldehyde derived from alcohol consumption is associated with bladder cancer risk.

Methods
A population-based cohort study was conducted to determine the association between the flushing response, as a surrogate marker of the capacity of acetaldehyde metabolism, and risk for bladder cancer.

Results
Of 95915 patients, 354 men and 110 women were newly diagnosed with bladder cancer.
No significant association existed between alcohol consumption and bladder cancer risk.
Among male flushers, HRs were 1.04, 1.67, 1.02, and 0.63 for alcohol consumption of 1-150, 151-300, 301-450, and greater than 450 g/week of pure ethanol compared with non- and occasional drinkers, respectively, indicating an inverted U-shaped association between alcohol consumption and bladder cancer risk.
No significant association was identified among male non-flushers.