Di Bonito P, Mozzillo E, Rosanio FM, et al. - Researchers conducted this multicenter cross-sectional study for analyzing factors associated with albuminuric and non-albuminuric mildly reduced estimated GFR (eGFR) phenotypes in youths with type 1 diabetes. Participants in the study were 1,549 youths, aged 5 to 17 years, with type 1 diabetes enrolled at 14 Italian Pediatric Diabetes Centers. Albuminuria, creatinine, glycosylated hemoglobin, lipids, blood pressure, neutrophils and lymphocytes count have been analyzed. Using bedside Schwartz’s equation, eGFR was calculated. The non-albuminuric mildly reduced GFR phenotype is more common than the albuminuric phenotype and has the worst cardiometabolic risk (CMR) profile. Both phenotypes have been linked to autoimmune thyroiditis. The findings suggest that albuminuria and eGFR should be assessed earlier in type 1 diabetes to identify young people with altered CMR profiles.