Connor JP, et al. - This study is performed to investigate the expression of AKR1B10 in cystic pancreatic lesions as a potential biomarker of malignancy. AKR1B10 is up-regulated in mucinous cystic pancreatic tumors and this staining can be accomplished in cytology fine-needle aspiration (FNA) material making AKR1B10 a promising biomarker of malignant potential. Most importantly this application could affect the clinical management of these patients by ascertaining the best candidates for surgical resection.