Malmström K, Lohi J, Malmberg LP, et al. - Among infants with wheeze and troublesome breathing, researchers undertook this investigation to determine airway hyperresponsiveness, remodeling and inflammation in this group. The following were included in the inclusion criteria: full‐term, 3‐23 months of age; doctor ‐diagnosed wheeze and persistent recurrent troublesome breathing; without obvious structural defect, suspicion of ciliary dyskinesia, cystic fibrosis, immune deficiency or specified use of corticosteroids. This analysis involved 49 eligible infants. A correlation of impaired baseline lung function with airway hyperresponsiveness (AHR) was observed. In this study, the results did not lend support to the concept that in very young children with wheeze, AHR is determined by eosinophilic inflammation or clear‐cut remodeling although it was related to impaired baseline lung function. In atopic children with AHR, the likely link of increased airway smooth muscle area is yet to be verified.