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Age-specific prevalence and incidence of dementia diagnoses in older US adults with schizophrenia

JAMA Psychiatry Jun 05, 2021

Stroup TS, Olfson M, Huang C, et al. - Researchers aimed at determining the age-specific incidence and prevalence of dementia among older US adults with schizophrenia and in a comparison group without serious mental illness (SMI). They conducted a cohort study of 8,011,773 individuals in a national Medicare database from 2007 to 2017. Findings revealed that at 66 years of age, 27.9% of individuals with schizophrenia also had a dementia diagnosis compared with 1.3% of individuals without a SMI. Among people with schizophrenia, dementia diagnosis prevalence at 66 years of age was similar to the prevalence at 88 years of age for the group without SMI. This increased risk is possibly because of cognitive and functional deterioration related to schizophrenia or factors contributing to other types of dementia. These findings suggest the necessity for further study concerning the processes and impairments that result in dementia diagnoses in patients with schizophrenia as well as prevention and treatment strategies.

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