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Age-related evolution of EEG in Dravet syndrome: Meta-analysis of 155 patients

Seizure - European Journal of Epilepsy Jun 16, 2021

Minato E, et al. - Given that Dravet syndrome is an early-onset developmental and epileptic encephalopathy caused by pathogenic SCN1A variants in 80-90% of patients, researchers conducted this investigation to analyze the age-related evolution of EEG in Dravet syndrome. In July 2020, they searched Pubmed for studies that included: ≥ 1 patient with Dravet syndrome clinical diagnosis and SCN1A pathogenic variant, and for each such patient, a description of ≥ 1 EEG and age at the time of the EEG. Two hundred forty-seven EEGs from 155 patients (from 31 studies and our research database) were included. Generalized epileptiform discharges, focal epileptiform discharges, diffuse background slowing, and focal slowing were first reported at six months, four months, four months, and four months, respectively. The results help to clarify the link between age and EEG in Dravet syndrome, however, given the inherent potential biases in the study design, findings should be interpreted with caution.

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