Takayama W, Endo A, Koguchi H, et al. - In view of the reported predictive value of age and coagulopathy for poor outcome after traumatic brain injury (TBI), researchers sought to ascertain the age-related disparities in the impact of coagulopathy on the outcome following isolated TBI. In this retrospective observational study conducted in two tertiary emergency critical care medical centers in Japan from 2013 to 2018, they assessed 1,036 patients with isolated TBI (head Abbreviated Injury Scale ≥ 3 and other Abbreviated Injury Scale < 3); the patients comprised 501 nonelderly (16–64 years) and 535 elderly cases (age ≥ 65 years). The multivariate model indicated a significant correlation of age and TBI-associated coagulopathy with lower Glasgow Outcome Scale-Extended [GOS-E] scores, in-hospital mortality, and shorter ventilation-free days in the nonelderly group. Coagulopathy was observed to have a low influence on functional and survival outcomes in geriatric patients with isolated TBI.