Baerwald A, et al. - Whether or not the development of luteal phase dominant follicles (LPDFs) as women age is associated with abnormal luteal function was determined. The development of LPDFs as women age was observed to be associated with reduced luteal growth, greater estradiol, lower progesterone, and lower inhibin A. Findings thereby provide preliminary evidence that during the menopausal transition, variations in antral folliculogenesis contribute to luteal insufficiency.