Martins-Klein B, et al. - Researchers examined the sources of stress related to cancer diagnosis and treatment and its association with age and emotional health among 147 individuals (aged 27–88; 98% male) with oral-digestive cancers. In addition, they determined the adaptive strategies mentioned within discussions of stress, which are classified as spontaneous emotion regulation (ER). Semi-structured interviews were undertaken among participants investigating sources of stress 6-months postdiagnosis and treatment-related stress at 12-months postdiagnosis. At diagnosis, the greatest source of stress was psychological; at treatment, the greatest source of stress was physical symptoms. Psychological uncertainty, social stress, and situational stress were less frequent among older adults, whereas physical stress was evident at similar rates in age groups. When describing stress, older adults more often made spontaneous references to ER. Across age groups, higher emotional distress on the PROMIS-29 was reported by those who reported stress without ER in qualitative comments than those reporting stress with ER or no stress. These findings suggest ER to be a key to psychological adjustment to cancer, particularly in later-life.