Brenes-Chacon H, Garcia-Mauriño C, Moore-Clingenpeel M, et al. - This study was conducted in lieu of a lack of knowledge concerning age-dependent differences in clinical presentation and viral loads in infants and young children with respiratory syncytial virus (RSV) infection, and their correlation with disease severity. Researchers here enrolled 534 previously healthy children < 2 years old with RSV infection; 130 of these were outpatients with mild RSV infection and 404 were inpatients with severe RSV disease. Observations revealed significant impact of age defining the interactions among viral loads, specific clinical manifestations and disease severity in children with RSV infection. In bivariate analyses, outpatients of older age (> 3 months) more frequently had presence wheezing than inpatients, while fever was more common in inpatients than outpatients and increase in its frequency was noted with age. Adjusted analyses affirmed the consistent correlation of increased work of breathing and fever with hospitalization irrespective of age, while reduced disease severity was observed in children > 6–24 months in independent correlation with wheezing in infants > 3 months, and higher RSV loads.