Majerczak J, Grandys M, Frołow M, et al. - Researchers performed this study on 94 males with varied training backgrounds, to determine how endothelial function and arterial stiffness in older age is influenced by long-lasting professional physical training (endurance and sprint) performed at a young age, taking into account glycocalyx injury, prostacyclin and nitric oxide production, inflammation, basal blood lipid profile, and glucose homeostasis. Participants included young athletes (mean age ∼25 years), older former high class athletes (mean age ∼60 years). They also included aged-matched untrained control groups. They found that endothelial function and arterial stiffness in the former athletes were not influenced by the training performed at a young age. Moreover, blood lipid profile, markers of inflammation, and glycocalyx shedding seen in former athletes remained uninfluenced by training performed at a young age. An increase in arterial stiffness and reduction in endothelial function was brought about by aging. Findings clearly highlighted the main contribution from aging, but not physical training history, to the observed reduction in endothelial function and rise in arterial stiffness in former athletes.