Vinke PC, et al. - Researchers used the Dutch population-based Lifelines Cohort to determine if age and gender could modify the strength of the link between diet quality and 4-y weight change, given diet quality is generally crucial in the prevention of unintentional weight gain. This analysis included 85,618 nonobese adult participants (age 18–93 y). By means of a 110-item food-frequency questionnaire, the evaluation of diet was done at baseline. The evaluation of diet quality was done by computing the Lifelines Diet Score, based on international evidence for diet-disease relations at the food group level. Findings revealed a link between poor diet quality and higher weight gain, particularly in young adults. In contrast, higher weight loss was observed in relation to poor diet quality in women aged ≥70 y. Thus, a promising target for undesirable weight alterations in both directions is a healthful diet.