Solanki P, Gwini SM, Doery JCG, et al. - As a specific aldosterone/renin ratio (ARR) threshold has been used by current Endocrine Society Clinical Practice Guidelines to screen for primary aldosteronism (a treatable disease causing up to 15% of hypertension in primary care) in all patients, researchers aimed at characterize demographic variations in the ARR, hypothesizing that age‐ and gender‐specific reference ranges maybe required to enhance the accuracy of the test. In this retrospective cross‐sectional analysis, they included data from 442 patients with clinically‐indicated ARR. Among those aged 20‐39 years old, females exhibited significantly higher aldosterone and ARR despite a lower systolic and diastolic BP, highlighting the potential for false positive results. Significant gender differences in the ARR were also observed in the ≥ 60 year age group (n = 157). With increasing age (20‐39 vs ≥ 60 years), a significant fall in plasma aldosterone was observed in females (369 pmol/L vs 264 pmol/L), however, males exhibited no change. Findings thereby suggest the necessity for prospective studies with a control population to define age‐ and gender‐specific ARR reference ranges.