Scrutinio D, Guida P, Aliani M, et al. - Since the impact of comorbidity on prognosis of obstructive sleep apnoea syndrome (OSAS) as well as their role for risk stratification is poorly defined, therefore, researchers explored these via this study with 1,592 patients with severe OSAS diagnosed by polysomnography. All-cause mortality was the primary outcome. The following factors were independently linked with mortality risk: age, gender, obesity, cardiovascular diseases, moderate-to-severe chronic obstructive pulmonary disease, chronic kidney disease and malignancy. Findings revealed elevated risk for all-cause death in relation to severe OSAS. In severe OSAS cases, important predictors of mortality were age and comorbidity. Detection of clinically meaningful phenotypes is enabled by clustering patients based on comorbidities.