Liccioli G, Mori F, Parronchi P, et al. - Given the lack of data on the incidence, triggers, and treatment of severe cutaneous adverse reactions (SCARs) from large-scale epidemiological investigations in the pediatric population, researchers gathered epidemiological, clinical and etiological data from children with SCARs who were referred to their tertiary-care paediatric hospital of Florence. Overall, 54 children, with a median age of 6.5 years, and 31 males, 23 females, were enrolled. In hospitalized children, the incidence of SCARs was estimated to be 0.32% during a 9-year time frame. The reported incidence of SCARs was in line with literature data. Drug allergy investigations were performed on 28 patients and 50% of them resulted positive. Most commonly, drugs were documented as the chief cause. As far as the management of SCARs was concerned, a need for cooperation among professional figures was realized for an early diagnosis and a prompt treatment. Children seemed to have a lower mortality rate.