Shah NS, Lloyd‐Jones DM, Kandula NR, et al. - Researchers analyzed national trends in premature cardiometabolic mortality, overall, and by race‐gender groups in the United States from 1999 to 2018. During this time period, premature deaths (< 65 years of age) from heart disease, cerebrovascular disease, and diabetes mellitus were quantified. A rise was noted in annual premature deaths from heart disease (117,880 to 128,832), cerebrovascular disease (18,765 to 20,565), and diabetes mellitus (16,553 to 24,758) as an underlying reason for death, from 1999 to 2018. Of all heart disease deaths, all cerebrovascular disease deaths, and all diabetes mellitus deaths, by 2018, 19.7%, 13.9%, and 29.1% were premature, respectively. Higher age‐adjusted mortality rates (AAMRs) and greater years of potential life lost (YPLL) for each cardiometabolic cause were reported in Black men and women vs White men and women, respectively. Overall, findings revealed that over one‐fifth of cardiometabolic deaths happened at < 65 years of age. Persistent racial differences worsen the recent stagnation in cardiometabolic AAMRs and YPLL.