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Adverse events during oral colchicine use: A systematic review and meta-analysis of randomised controlled trials

Arthritis Research & Therapy Evidence based | Feb 19, 2020

Stewart S, Yang KCK, Atkins K et al. - A systematic review and meta-analysis of randomized controlled trials were conducted to analyze the side effect profile of colchicine in controlled clinical trials across all published indications. A systematic review was conducted in accordance with the PRISMA methodology. The Cochrane Library, MEDLINE and EMBASE were searched for double-blind controlled trials of oral colchicine in adult patients that reported adverse event data. They applied meta-analyses to ascertain the relative risk (RR) of adverse events in colchicine users compared with comparator groups. Researchers recruited a sum of 4,915 studies that were initially distinguished and after exclusions, 35 randomized controlled trials with placebo (n = 35) or active comparators (n = 5). The results of this study showed that colchicine improves the rate of diarrhoea and gastrointestinal adverse events but does not improve the rate of the liver, sensory, muscle, infectious or haematology adverse events or death.
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