Lehto J, Gunn J, Björn R, et al. - Given the relatively common occurrence of postpericardiotomy syndrome (PPS) following cardiac surgery, researchers here examined the long-term follow-up data on the adverse events and mortality of PPS patients requiring invasive interventions. The analysis of a combination database of 671 patients undergoing isolated surgical aortic valve replacement with a bioprosthesis (n = 361) or mechanical prosthesis (n = 310) between 2002 and 2014 (CAREBANK 2016–2018) revealed an overall incidence of PPS of 11.2%. Among these patients, the median time to diagnosis was 16 (interquartile range 11–36) days. The diagnosis of severe PPS was made in 3.6% of patients. The risk for mortality was higher among patients with PPS who require invasive interventions vs those with mild to moderate forms of the disease. Higher atrial fibrillation rate during the early postoperative period was correlated with PPS requiring medical attention but this has no significant influence on the occurrence of a major stroke, stroke or transient ischemic attack, or major bleeds during long-term follow-up.