Esteves KC, Jones CW, Wade M, et al. - Researchers examined how maternal adverse childhood experiences (ACEs) influence both the trajectory of infant telomere length (TL) and infant social-emotional problems at 18 months of age. Recruiting pregnant women, they obtained maternal scores on the Adverse Childhood Experience questionnaire, along with their demographic and prenatal stress measures. At postnatal visits when infants were 4, 12, and 18 months of age, infant buccal swabs were collected for TL measurement, and mothers completed measures of maternal depression. In addition, the Child Behavior Checklist was completed by mothers at the 18-month visit. Analysis of the obtained information suggests an association of higher maternal ACEs with shorter infant TL across infancy and higher infant externalizing behavioral problems at 18 months. Infants of mothers reporting higher scores on the Adverse Childhood Experience questionnaire had higher externalizing problems in relation to greater telomere attrition, even when accounting for maternal postnatal depression and prenatal stress. Data thereby illustrate an interactive pathway between maternal early-life adversity and infant TL that prognosticates emerging behavioral problems in the next generations.