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Adult height after gonadotropin‐releasing hormone agonist treatment in girls with early puberty: A meta‐analysis

Clinical Endocrinology Jun 08, 2020

Park HK, et al. - Researchers conducted this meta‐analysis to analyze the impacts of gonadotropin‐releasing hormone (GnRH) agonist treatment on adult height and the factors correlated with adult height outcomes. Included were a total of 14 studies found through an online database search (AMED, EMBASE, MEDLINE and RISS). Controlled studies were selected with girls who developed puberty before the age of 10, and measurements of the individuals' adult heights. Studies have been included which use only long-acting GnRH agonists to suppress puberty. The individuals' mean age ranged from 6.3 to 9.0 years. The difference in height between the treated subjects and controls was significantly linked to treatment duration rather than age at treatment start or difference between bone age and chronological age. GnRH agonists administered in girls who develop early puberty and show advanced bone age may be effective in increasing adult height, particularly if a sufficiently long duration of treatment can be achieved.

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