Adrenaline and cortisol levels are lower during nighttime than daytime hypoglycaemia in children with type 1 diabetes
Acta Pediatrica Apr 27, 2018
Fredheim S, et al. - The children's counter regulatory hormone profiles were scrutinized by experts during a hyperinsulinaemic hypoglycaemic clamp procedure at day and night in outpatients with type 1 diabetes, recruited from the Herlev Hospital, Denmark, at a mean age of 9.6 ± 2.3 years. Data illustrated higher adrenaline and growth hormone levels during the day compared to the night. At the glucose nadir, lower level of adrenaline was discovered during the night than the day and cortisol was found to be lower during the day than the night. Yielded data depicted that the adrenaline response was blunted during nocturnal iatrogenic hypoglycaemia, with no increase in the cortisol levels.
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