Pizon AF, et al. - Whether using an adjunctive ketamine infusion improves outcomes in patients suffering from severe ethanol withdrawal was investigated among ICU patients diagnosed with delirium tremens. In utilizing adjunctive therapy with ketamine, possible reduction may be seen in the demonstrated neuroexcitatory contribution of N-methyl-D-aspartate receptor stimulation in severe ethanol withdrawal. Furthermore, it may attenuate the need for excessive gamma-aminobutyric acid agonist mediated–sedation and limit related morbidity. In relation to a ketamine infusion, in patients with delirium tremens, reduced gamma-aminobutyric acid agonist needs, shorter ICU length of stay, lower likelihood of intubation, and a trend toward a shorter hospitalization were observed.