Hagan KA, et al. – In this study consisting of 205,935 participants from Nurses' Health Studies (NHS/NHS II) and Health Professionals Follow-Up Study (HPFS), researchers ascertained if earlier-life adiposity or other measures of adult adiposity are associated with venous thromboembolism (VTE) risk. After accounting for adult body mass index (BMI), somatotype in childhood and young adulthood BMI were not significantly correlated with VTE risk. Even after adjusting for adult BMI, adult waist circumference was related to greater VTE risk. After adjusting for current BMI among women only, increasing weight gain from young adulthood was significantly linked to VTE. In the etiology and prevention of VTE, BMI and adiposity were likely more important acutely than cumulatively over time. Clinically, encouraging weight loss in overweight or obese individuals could help reduce the risk of VTE.