Adipose tissue distribution and cardiovascular disease risk among breast cancer survivors
Journal of Clinical Oncology Oct 04, 2019
Feliciano EMC, Chen WY, Bradshaw PT, et al. - Researchers examined the link between adipose tissue distribution and the risk of cardiovascular disease (CVD) among breast cancer survivors. The incidence of nonfatal stroke, myocardial infarction, heart failure, or CVD death was assessed in patients (n = 2,943) with nonmetastatic breast cancer without previous CVD, using International Classification of Diseases (9th and 10th revisions) codes. Visceral adiposity, subcutaneous adiposity, and intramuscular adiposity were measured from clinically obtained computed tomography scans taken near diagnosis. Findings revealed the link of visceral and intramuscular adiposity, with elevated CVD incidence following breast cancer diagnosis, independent of pre-existing CVD risk factors and cancer treatments. Considering BMI alone would not allow the detection of elevated CVD incidence among normal-weight patients with greater visceral adiposity. High-risk patients may be recognized and CVD prophylactic strategies may be tailored via measures of adipose tissue distribution.
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