Pishgar F, Shabani M, Silva TQAC, et al. - The researchers discovered a link between intermuscular adipose tissue (IMAT) at baseline and type 2 diabetes (T2D) incidence over the course of the study. This study suggests that intermuscular adipose depots may play a role in the pathophysiology of T2D.

• Between 2010 and 2012, 1,744 normoglycemic participants with chest CT exams were evaluated.

• At the start of the study, the average age of the participants was 69 ± 9 years, with 977 (56.0%) of them being female.

• Over the course of 7 years, 103 (5.9%) of the patients were diagnosed with T2D, and 147 (8.4%) died.

• The IMAT index and the subcutaneous adipose tissue [SAT] index at baseline were linked to T2D incidence over the follow-up.

• After adjusting for BMI and waist circumference, the correlations of the IMAT and SAT indices with T2D incidence were diminished, with hazard ratios of 1.23 and 1.29 per 1-standard deviation rise, respectively.

• Unmeasured residual confounders and one-time detection of adipose tissue biomarkers are two of the study's weaknesses.