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Adiponectin is increased in pediatric patients with autoimmune hepatitis independent of body weight

Journal of Pediatric Gastroenterology Sep 25, 2020

Cortez APB, de Azevedo RA, Fisberg M, et al. - Researchers conducted this case-controlled study to explore the connection between excess weight, defined by a BMI/age Z score >+1 standard deviation, and systemic inflammation, adipokines, and ghrelin in adolescents with autoimmune hepatitis (AIH). The sample consisted of 27 adolescents with AIH (13 with excess weight and 14 with normal weight) and a control group. According to results, adiponectin (μg/mL) was higher in AIH adolescents with and without excess weight than in normal-weight (17.5) and excess-weight (17.0) controls. AIH patients had higher adipokines levels, especially adiponectin and IL-6, regardless of body weight. The levels of leptin were related to body weight and were not affected by AIH. Lean tissue in AIH was correlated with IL-10 levels.

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