Everson‐Rose SA, Barinas‐Mitchell EJM, El Khoudary SR, et al. - Among females aged 54 to 65 years, this cross‐sectional analysis was conducted to assess the links of adiponectin and leptin with carotid artery intima‐media thickness, adventitial diameter, presence of carotid plaques, and brachial‐ankle pulse wave velocity (baPWV). Participants were selected from a community‐based study of females transitioning through menopause (SWAN: Study of Women's Health Across the Nation). This analysis involved 1,399 women. Lower concentrations of adiponectin were identified to be associated with greater carotid artery intima‐media thickness, wider adventitial diameter, and faster baPWV; links were reduced post-adjustment for cardiovascular disease risk factors. Higher concentrations of leptin were found to be related to greater carotid artery intima‐media thickness and wider adventitial diameter in minimally as well as completely adjusted models, and contrary to expectation, to slower baPWV, especially in females having diabetes mellitus or obesity. Overall, adiponectin and leptin were recognized as two crucial inflammatory pathways that may represent as contributors to adverse subclinical cardiovascular disease risk profiles in females at midlife.