Colantonio LD, et al. - Researchers performed this retrospective cohort study to determine statin persistence and adherence in US adults aged ≥21 years who initiated statins in 2007–2014 and started treatment following a myocardial infarction (n=201,573), had diabetes mellitus but without coronary heart disease (CHD; n=610,049), or did not have CHD or diabetes mellitus (n=2,244,868). According to findings, among those initiating treatment following myocardial infarction, 78.1% and 79.1% of patients were found to be persistent with statin therapy in 2007 and 2014, respectively. For same time periods, the percentages were 66.5% and 67.3%, respectively, for those with diabetes mellitus but without CHD; and 64.3% and 63.9%, respectively, for those without CHD or diabetes mellitus. Among patients initiating treatment following myocardial infarction and among those with diabetes mellitus but without CHD, high adherence to statin therapy increased from 57.9% to 63.8% and from 34.9% to 37.6%, respectively, between 2007 and 2014. Overall, a low persistence with and adherence to statin therapy was reported, specifically among those without CHD.