Shoval G, et al. - In a population-based cohort of patients with cancer, researchers examined how adherence to antidepressants (AD) correlates with all-cause mortality. Including 42,075 patients with cancer who purchased AD at least once during the study period, they conducted this 4-year historical prospective cohort study. They categorized AD adherence as nonadherence (<20%), poor (20–50%), moderate (50–80%), and good (>80%) adherence. Compared to the nonadherent group, the poor, moderate, and good adherence groups had the adjusted hazard ratios for mortality of 0.89, 0.77, and 0.80, respectively, over 1,051,489 person-years at risk follow-up. For the first time, this study demonstrated a decrease of all-cause mortality in a large nationwide cohort of cancer patients in correlation to higher adherence to AD. Data thereby support encouraging adherence to AD among cancer patients.